Broncos open as slight underdogs to Chiefs in MNF season opener

KANSAS CITY, MISSOURI - DECEMBER 25: Bo Nix #10 of the Denver Broncos runs the ball for a touchdown against the Kansas City Chiefs during the third quarter at Arrowhead Stadium on December 25, 2025 in Kansas City, Missouri. (Photo by Jamie Squire/Getty Images) | Getty Images Bo Nix and the Denver Broncos begin their AFC West title defense on the road. And the Broncos open the 2026 regular season against Patrick Mahomes and the Kansas City Chiefs on Monday Night Football.

Thus, it’s no surprise that Denver opens as slight road underdogs for the MNF opener at Arrowhead Stadium. FanDuel Sportsbook has the Broncos as +2. 5-point underdogs to Kansas City.

Denver is also +140 on the moneyline, and the total sits at over/under 43. 5 points, with a lean toward the under at -118. Since Nix and Denver are on the road at Arrowhead Stadium, it’s no surprise the Chiefs are favored.

You could get a sense of that based on the AFC West and AFC futures odds. Oddsmakers still love Mahomes and the Chiefs. KC is currently the favorite to win the division at +170, followed by the Los Angeles Chargers at +185 and the Broncos at +210.