Cubs vs Guardians Prediction, Picks & Odds for Tonight's MLB Game
Chicago Cubs vs. Cleveland Guardians predictions, picks, and odds for MLB action on Saturday, April 4.
Want to get more Covers content? Add us as a preferred source on your Google account here . The Chicago Cubs and Cleveland Guardians play the second of a three-game set at Progressive Field tonight.
Although Chicago fell 4-1 on Friday, my Cubs vs. Guardians predictions are backing the visitors to bounce back. Here are my top free MLB picks for this interleague showdown on Saturday, April 4.
Who will win Cubs vs Guardians today: Cubs moneyline (-126) The Cleveland Guardians are sending Slade Cecconi to the mound after he surrendered six runs in 4 1/3 innings in his season debut. He posted a 4. 99 xERA in 2025 and ranked second-worst in barrel rate and hard-hit rate among pitchers with at least 100 innings of work.
On the other side, the Chicago Cubs respond with southpaw Shota Imanaga , who pitched to a 3. 73 ERA with a 0. 99 WHIP last year.