Guardians vs Mariners Prediction, Odds & Home Run Pick for Tonight's MLB Game
Logan Gilbert and the Seattle offense are both center stage in our Guardians vs. Mariners predictions and Opening Day MLB picks.
Want to get more Covers content? Add us as a preferred source on your Google account here . The Cleveland Guardians open the season on the West Coast with a game against the Seattle Mariners tonight.
Both teams are coming off divisional titles and return with rosters mostly intact, if not upgraded. Seattle has an edge in the starting pitching matchup and brings in an absolutely stacked lineup, which is why my Guardians vs. Mariners predictions and MLB picks call for it to cover at home on Thursday, March 26.
Guardians vs Mariners predictions Guardians vs Mariners best bet: Mariners -1. 5 (+130) The Seattle Mariners were the fourth-best hitting team with a 113 OPS in 2025 and have been even better this spring. After scoring 4.
7 runs per game last year, Seattle averaged 5. 5 in spring training. Logan Gilbert was effective as usual when healthy last season, finishing with a 3.