March Madness Upset Predictions: Best Sweet 16 Picks for 2026
Jason Ence's March Madness upset picks for the Sweet 16 see St. John's sending Duke home from the 2026 NCAA Tournament on Friday night.
Want to get more Covers content? Add us as a preferred source on your Google account here . The second weekend of the NCAA Tournament is upon us, and an exciting opening weekend saw a No.
1 seed bite the dust, while another one narrowly escaped an historic first-round exit. While there may only be one double-digit seed remaining, there’s still plenty of opportunity for a surprise result and an underdog victory. Here are my top March Madness picks and upset predictions for the Sweet 16.
Our favorite March Madness upset picks for the Sweet 16 Team Odds Iowa moneyline +110 St. John’s moneyline +230 No. 9 Iowa vs No.
4 Nebraska South Region, Thursday @ 7:30 p. m. ET, TBS The Iowa Hawkeyes and the Nebraska Cornhuskers have faced off twice this season, with the home team coming away victorious each time.