Predicting winners in MLB on Thursday, March 26th, 2026
Winning in MLB on a daily basis is one of the toughest challenges in sports. With 162 games, constant lineup changes, pitching matchups, and the unpredictable nature of baseball, picking winners isn’t about guessing—it’s about analyzing matchups and picking up on patterns. Every day presents a new slate, new opportunities, and new value.
From analyzing starting pitchers and bullpen usage to identifying hot lineups and favorable matchups, success comes from staying consistent and trusting the process over the long haul. Here are today’s MLB predictions for final scores and the winners around the league. MORE: 5 MLB rookies to keep your eyes on in 2026 Pirates at Mets Sep 4, 2025; Pittsburgh, Pennsylvania, USA; Pittsburgh Pirates starting pitcher Paul Skenes (30) delivers a pitch against the Los Angeles Dodgers during the first inning at PNC Park.
Mandatory Credit: Charles LeClaire-Imagn Images Pitching Matchup: Paul Skenes vs. Freddy Peralta Score Prediction: 4-3 Winner: Mets White Sox at Brewers Pitching Matchup: Shane Smith vs. Jacob Misiorowski Score Prediction: 6-3 Winner: Brewers Nationals at Cubs Pitching Matchup: Cade Cavali vs.
Matthew Boyd Score Prediction: 7-2 Winner: Cubs Twins at Orioles Sep 26, 2025; Philadelphia, Pennsylvania, USA; Minnesota Twins pitcher Joe Ryan (41) throws a pitch during the second inning against the Philadelphia Phillies at Citizens Bank Park. Mandatory Credit: Bill Streicher-Imagn Images Pitching Matchup: Joe Ryan vs. Trevor Rogers Score Prediction: 4-1 Winner: Orioles Red Sox at Reds Pitching Matchup: Garrett Crochet vs.
Andrew Abbott Score Prediction: 8-5 Winner: Red Sox Tigers at Padres Pitching Matchup: Tarik Skubal vs. Nick Pivetta Score Prediction: 5-4 Winner: Padres Angels at Astros Sep 24, 2025; West Sacramento, California, USA; Houston Astros pitcher Hunter Brown (58) delivers a pitch against the Athletics in the first inning at Sutter Health Park. Mandatory Credit: Cary Edmondson-Imagn Images Pitching Matchup: Jose Soriano vs.