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March Madness Picks: Score Predictions for Every Sweet 16 Game

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Rohit Ponnaiya delivers game-by-game final score predictions for every Sweet 16 game for the 2026 edition of March Madness. Free Sweet 16 March Madness picks for March 26 & 27.

Want to get more Covers content? Add us as a preferred source on your Google account here . After a wild opening week to March Madness, the NCAA Tournament is down to the final 16 teams.

I predicted the scores for every first-round game, and while I had my share of misses, I also nailed a few — including upsets by No. 11 seeds VCU and Texas. I'm not predicting any outright upsets for this round, but there are betting angles I like based on my projected scores.

These predictions are based on a combination of my own ratings, along with the data analysts at KenPom, Bart Torvik, Evan Miya, and Haslametrics. Here are my March Madness picks for every game in the Sweet 16. March Madness score predictions Matchup Score prediction Implied score Betting edge Texas vs Purdue 80-73 78-71 Over 148 -110 Iowa vs Nebraska 68-66 67-65 Over 131.

5 -110 Arkansas vs Arizona 88-78 87-79 Arizona -7. 5 -110 Illinois vs Houston 74-70 72-69 Over 140 -110 St. John's vs Duke 72-68 74-67 St.

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