Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats
By Gregory R. Smith, Bingqing Zhao, Malene E. Lindholm, Archana Raja, Mark Viggars, Hanna Pincas, Nicole R. Gay, Yifei Sun, Sindhu Vangeti, Yongchao Ge, Venugopalan D. Nair, James A. Sanford, Mary Anne S. Amper, Mital Vasoya, Kevin S. Smith, Irene Ramos, Stephen B. Montgomery, Elena Zaslavsky, Sue C. Bodine, Karyn A. Esser, Martin J. Walsh, Michael P. Snyder, Stuart C. Sealfon, Joshua N. Adkins, Brent G. Albertson, David Amar, Mary Anne S. Amper, Jose Juan Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Ali Tugrul Balci, Marcas Bamman, Nasim Bararpour, Elisabeth R. Barton, Pierre M. Jean Beltran, Bryan C. Bergman, Daniel H. Bessesen, Sue C. Bodine, Frank W. Booth, Brian Bouverat, Thomas W. Buford, Charles F. Burant, Tiziana Caputo, Steven Carr, Toby L. Chambers, Clarisa Chavez, Maria Chikina, Roxanne Chiu, Michael Cicha, Clary B. Clish, Paul M. Coen, Dan Cooper, Elaine Cornell, Gary Cutter, Karen P. Dalton, Surendra Dasari, Courtney Dennis, Karyn Esser, Charles R. Evans, Roger Farrar, Facundo M. Fernández, Kishore Gadde, Nicole Gagne, David A. Gaul, Nicole R. Gay, Yongchao Ge, Robert E. Gerszten, Bret H. Goodpaster, Laurie J. Goodyear, Marina A. Gritsenko, Kristy Guevara, Fadia Haddad, Joshua R. Hansen, Melissa Harris, Trevor Hastie, Krista M. Hennig, Steven G. Hershman, Andrea Hevener, Michael F. Hirshman, Zhenxin Hou, Fang-Chi Hsu, Kim M. Huffman, Chia-Jui Hung, Chelsea Hutchinson-Bunch, Anna A. Ivanova, Bailey E. Jackson, Catherine M. Jankowski, David Jimenez-Morales, Christopher A. Jin, Neil M. Johannsen, Robert L. Newton Jr, Maureen T. Kachman, Benjamin G. Ke, Hasmik Keshishian, Wendy M. Kohrt, Kyle S. Kramer, William E. Kraus, Ian Lanza, Christiaan Leeuwenburgh, Sarah J. Lessard, Bridget Lester, Jun Z. Li, Malene E. Lindholm, Ana K. Lira, Xueyun Liu, Ching-ju Lu, Nathan S. Makarewicz, Kristal M. Maner-Smith, D. R. Mani, Gina M. Many, Nada Marjanovic, Andrea Marshall, Shruti Marwaha, Sandy May, Edward L. Melanson, Michael E. Miller, Matthew E. Mon…••Nature.com
The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.
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Google Scholar Mansueto, G. et al. Tr…