March Madness Upset Predictions: Best Second-Round Picks for 2026

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And while Friday offered very little in the way of upset wins, we got multiple March Madness upsets on Thursday thanks to the likes of High Point and VCU. The Round of 32 slate offers some very interesting matchups. I’ve keyed in on four that offer betting value in my underdog March Madness picks for the second round.

Our favorite March Madness upset picks for Round 2 Team Odds VCU moneyline +400 High Point moneyline +500 Kansas moneyline +125 UCLA moneyline +145 No. 11 VCU vs No. 3 Illinois South Region, Saturday @ 7:50 p.

m. ET, CBS March is defined by your performance in the clutch, and Illinois has lost six of its seven games this season decided by five or fewer points. Since a four-point win over Texas Tech in early November, they’ve lost the last six such games — the last four in overtime.