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March Madness Picks Against the Spread for Saturday, March 21

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Our March Madness against the spread picks for Saturday, March 21, feature Houston and Vanderbilt.

Want to get more Covers content? Add us as a preferred source on your Google account here . March Madness rumbles on as the Round of 32 tips off on Saturday morning with a matchup between the No.

9 Saint Louis Billikens and the No. 1 Michigan Wolverines, and concludes with the No. 12 High Point Panthers and No.

4 Arkansas Razorbacks. Let’s take a look at the spread for all eight games on tap for the Second Round of the NCAA Tournament. Here are my favorite March Madness picks against the spread (ATS) for each game on Saturday, March 21.

March Madness picks against the spread for Saturday, March 21 Matchup Pick Saint Louis vs Michigan +12. 5 Louisville vs Michigan State -4 TCU vs Duke +11 Texas A&M vs Houston -10 Texas vs Gonzaga +5. 5 VCU vs Illinois -10.

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