March Madness Moneyline Picks for Saturday, March 21
Our March Madness moneyline picks for all Round 2 games on Saturday, March 21. High Point provides another upset.
Want to get more Covers content? Add us as a preferred source on your Google account here . The 2026 edition of March Madness continues on Saturday with eight games on the NCAA Tournament schedule.
We’ve already seen our share of upsets, and my second-round college basketball predictions are looking at three potential Round of 32 underdog wins. Read on for my March Madness picks for Saturday, March 21. March Madness moneyline picks on Saturday, March 21 Matchup Pick Saint Louis vs Michigan -900 Louisville vs Michigan State -170 TCU vs Duke +400 Texas A&M vs Houston -550 Texas vs Gonzaga -225 VCU vs Illinois -600 Vanderbilt vs Nebraska +120 High Point vs Arkansas +500 Lines courtesy of bet365.
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