Pro Picks: Your Midwest March Madness Gambles from Cinderellas to Champions Keeping Hearts Racing!
The Wolverines opened as the betting favorites to win the national title and it's hard to see how they won't make it out of the Midwest region.
With the 2026 NCAA men's tournament upon us, here's everything you need to know about the Midwest region. [More regional breakdowns: East | West | South ] Who are the favorites? Michigan ( +350 to win the national title at BetMGM ) Iowa State (16-1) Virginia (80-1) Michigan opened as the early favorite after the selection show, but is now firmly the No.
2 favorite behind Duke. Iowa State’s odds have slowly gotten better since the bracket was released, as bettors clearly like the draw the Cyclones got on their side of the bracket. Virginia, meanwhile, has the highest odds of any top-three seed to win the national title.
No. 5 seeds like Vanderbilt and St. John’s (66-1) have better odds to win it all than the Cavaliers do.
[ Yahoo Fantasy Bracket Mayhem is back: Enter for a shot to win up to $50K ] When will the No. 1 seed go down? It’s hard to see how Michigan isn’t going to make the Final Four.
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